Evidence of Clinical Inertia in Management of T2DM

(HealthDay News) Many patients with type 2 diabetes (T2D) who have a hemoglobin A1c (HbA1c) level expected to trigger treatment intensification often have treatment inappropriately delayed, according to a research letter in Diabetes Care. “Unfortunately, these real-world findings confirm a high prevalence of clinical inertia with regard to T2D management,” the authors write.

Wed, 18 Jul 2018 ENDOCRINOLOGY
Circadian System, Misalignment Have Distinct Impact on Insulin

(HealthDay News) The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function, research in Diabetes, Obesity and Metabolism finds. The circadian system mainly decreases both dynamic and static β-cell responsivity to reduce glucose tolerance in the biological evening versus the biological morning. In contrast, circadian misalignment reduced glucose tolerance by lowering insulin sensitivity.

Wed, 11 Jul 2018 ENDOCRINOLOGY
Aspirin Use Doesn’t Cut Cancer Incidence in Older T2DM Patients

(HealthDay News) For Japanese patients with type 2 diabetes, low-dose aspirin is not associated with reduced cancer incidence, except in those younger than 65 years, research in Diabetes Care suggests. Researchers conducted a post-trial follow-up of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes trial and found there was no significant difference between the aspirin and no-aspirin groups in terms of cancer incidence.

Wed, 27 Jun 2018 ENDOCRINOLOGY
BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

(HealthDay News) The Bacillus Calmette Guérin (BCG) vaccine is associated with a reduction in hyperglycemia among patients with type 1 diabetes with long-term disease, research in npj Vaccines suggests. The researchers found that BCG lowered hemoglobin A1c to near-normal levels after year 3 for the next five years. A novel systemic and blood sugar-lowering mechanism drove the BCG impact on blood sugars.

Fri, 22 Jun 2018 ENDOCRINOLOGY
HbA1c Targets Should Be Personalized in Type 2 Diabetes

(HealthDay News) For non-pregnant adults with type 2 diabetes, hemoglobin A1c (HbA1c) targets should be personalized, according to a Clinical Guidelines Synopsis in the Journal of the American Medical Association. Personalization for patients with type 2 diabetes should be based on discussions of the benefits and harms of pharmacotherapy, patient preferences, health, and life expectancy; the burden of treatment; and costs associated with care.

Wed, 20 Jun 2018 ENDOCRINOLOGY
Cleared Blood Glucose Monitor Systems Not Always Accurate

(HealthDay News) One in three commercially available blood glucose monitor systems (BGMs) meet a predefined accuracy standard, research in Diabetes Care finds. Researchers recruited 1,035 subjects to have blood glucose measured on six different systems plus a reference lab sample. BGMs were obtained from consumer outlets and tested in three triple-blinded studies. The accuracy standard was not met in any of the studies.

Mon, 18 Jun 2018 ENDOCRINOLOGY