Metformin Tied to Acidosis Risk at eGFR

Metformin use is associated with an increased risk of acidosis at estimated glomerular filtration rate (eGFR) <30mL/min/1.73 m², research in JAMA Internal Medicine finds. Researchers quantified the correlation between metformin use and hospitalization with acidosis among 75,413 patients with diabetes. The results were replicated in 67,578 new metformin users and 14,439 new sulfonylurea users from 2010 to 2015. "Our results support cautious use of metformin in patients with type 2 diabetes," the authors write.

Thu, 12 Jul 2018 BREAKING NEWS
Apixaban Is Safest Direct Oral Anticoagulant Versus Warfarin

(HealthDay News) Apixaban seems to be the safest direct oral anticoagulant (DOAC) compared with warfarin, according to research in The BMJ. “Overall, apixaban was found to be the safest drug, with reduced risks of major, intracranial, and gastrointestinal bleeding compared with warfarin,” the authors write. “Rivaroxaban and low-dose apixaban were, however, associated with increased risks of all-cause mortality compared with warfarin.”

Wed, 11 Jul 2018 FAMILY PRACTICE
Circadian System, Misalignment Have Distinct Impact on Insulin

(HealthDay News) The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function, research in Diabetes, Obesity and Metabolism finds. The circadian system mainly decreases both dynamic and static β-cell responsivity to reduce glucose tolerance in the biological evening versus the biological morning. In contrast, circadian misalignment reduced glucose tolerance by lowering insulin sensitivity.

Wed, 11 Jul 2018 ENDOCRINOLOGY
CDC: Nearly One-Third of Injury Deaths Occur at Home

Just under one-third of deaths from all causes of injury occur in the person’s home, according to a QuickStats report published in the CDC’s Morbidity and Mortality Weekly Report. In 2016, the total number of deaths by all injury types was 231,991. “More than half of the deaths attributable to poisoning (52%) occurred in the home,” the authors write. “Approximately 44% of deaths from firearms and suffocation occurred in the home.”

Wed, 11 Jul 2018 BREAKING NEWS
Attending Surgeon Influences Genetic Testing in Breast Cancer

The attending surgeon is associated with variation in the receipt of genetic testing after breast cancer diagnosis, according to research in JAMA Surgery. The researchers found that 34.5% of patients had an elevated risk of mutation carriage and 27.0% underwent genetic testing. There was a more than two-fold increase in the odds of a patient receiving genetic testing if she saw a surgeon with an approach one standard deviation above that of a surgeon with the mean test rate.

Wed, 11 Jul 2018 BREAKING NEWS
Transfeminine Persons Have Increased VTE Incidence

(HealthDay News) Transfeminine individuals have increased rates of venous thromboembolism (VTE) compared with cisgender men and cisgender women, with more pronounced differences for those initiating hormone therapy during follow-up, according to research published in the Annals of Internal Medicine. “These results may indicate the need for long-term vigilance in identifying vascular side effects of cross-sex estrogen,” the authors write.

Tue, 10 Jul 2018 CARDIOLOGY