First-Line Metformin Use for DM Up; Sulfonylurea Use Down

Among patients with type 2 diabetes initiating antidiabetes drugs (ADDs), first-line use of metformin has increased since 2005, while sulfonylureas have remained the most popular second-line agent, research in Diabetes Care suggests. Researchers identified patients with type 2 diabetes who initiated any ADD and patients who initiated second-line ADD after first-line metformin. They found that between 2005 and 2016, first-line use of metformin increased from 60 to 77%, while first-line use of sulfonylureas decreased from 20% to 8%.

Fri, 17 Nov 2017 BREAKING NEWS
FDA OKs Drug for Hemophilia A With Factor VIII Inhibitors

Hemlibra (emicizumab-kxwh) has been approved by the FDA to prevent or reduce the frequency of bleeding episodes among hemophilia A patients with Factor VIII inhibitors. The subcutaneously administered medication was approved to treat both adult and pediatric patients. The FDA granted Priority Review and Breakthrough Therapy designations, and Hemlibra has received Orphan Drug designation. Common adverse events include injection site reaction, headache, and arthralgia. Hemlibra is produced by Genentech, based in South San Francisco.

Fri, 17 Nov 2017 BREAKING NEWS
Attributes of High-Value Oncology Practices Identified

(HealthDay News) Attributes that distinguish high-value oncology practices have been identified, according to a study published in JAMA Oncology. Three attributes — early and normalized palliative care, ambulatory rapid response, and early discussion of limitations and consequences of treatment — were judged to have the highest immediate potential for reducing spending without compromising care quality.

FDA Investigation Linked to Drop in Codeine Rx for Children

The FDA investigation into the safety of codeine use by children, which culminated in a black box warning in February 2013, led to substantially decreased codeine prescribing to children after tonsillectomy and/or adenoidectomy, according to a study published in Pediatrics. The researchers found that the FDA investigation was associated with a significant −13.3 percentage point level change in the proportion of children with at least one prescription fill for codeine after tonsillectomy and/or adenoidectomy.

Fri, 17 Nov 2017 BREAKING NEWS
Sentinel Lymph Node Biopsy Underused in High-Risk SCC

(HealthDay News) Sentinel lymph node biopsy (SLNB) is underused for high-risk squamous cell carcinoma (SCC) of the skin, according to a research letter in JAMA Dermatology. “Given the cost and morbidity associated with prophylactic lymph node dissection, patients may benefit from a less invasive SLNB procedure before considering dissection,” the authors write.

Fri, 17 Nov 2017 DERMATOLOGY
Virtual Reality Effective for Post-Stroke Upper Extremity Rehab

(HealthDay News) Virtual reality (VR) training is as effective as conventional training for upper extremity rehabilitation after stroke, according to a study in Neurology. “Additional upper extremity VR training was not superior but equally as effective as additional CT in the subacute phase after stroke. VR may constitute a motivating training alternative as a supplement to standard rehabilitation,” conclude the authors.

Fri, 17 Nov 2017 NEUROLOGY