Number of Cigarettes Smoked Daily Tied to Stroke Risk

(HealthDay News) There is a strong dose-response relationship between the number of cigarettes smoked daily and ischemic stroke risk among men younger than 50, a study in Stroke suggests. Researchers found a dose-response relationship for stroke, when categorized by number of cigarettes smoked, with the odds ratio ranging from 1.46 for <11 cigarettes per day to 5.66 for ≥40 cigarettes per day.

Thu, 19 Apr 2018 CARDIOLOGY
Gene Therapy Found to Be Promising for β-Thalassemia

For patients with severe β-thalassemia, the need for red-cell transfusions can be reduced or eliminated by transducing cells with the LentiGlobin BB305 vector, according to a study published the New England Journal of Medicine. “Gene therapy with autologous CD34+ cells transduced with the BB305 vector reduced or eliminated the need for long-term red-cell transfusions in 22 patients with severe β-thalassemia without serious adverse events related to the drug product,” the authors write.

Thu, 19 Apr 2018 BREAKING NEWS
AAN: Erenumab Shows Promise for Hard-to-Treat Migraine

For patients with episodic migraine who have failed prior preventive migraine treatments (PMTs), erenumab is associated with an increase in the proportion of patients achieving a ≥50 percent reduction in mean monthly migraine days (MMDs), according to a study presented at the annual meeting of the American Academy of Neurology, in Los Angeles. “Our results show that people who thought their migraines were difficult to prevent may actually have hope of finding pain relief,” author Uwe Reuter, M.D., said.

Thu, 19 Apr 2018 BREAKING NEWS
Cellular Biomedical Tattoo Can ID Hypercalcemia-Linked Cancer

(HealthDay News) A cell-based biomedical tattoo can detect hypercalcemia associated with cancer in a murine model, an experimental study in Science Translational Medicine suggests. Researchers designed cells containing an ectopically expressed calcium-sensing receptor rewired to a synthetic signaling cascade that activates expression of transgenic tyrosinase; in response to persistently increased blood Ca2+, melanin is produced and can be quantified optically.

Opiate Use Linked to Early Mortality in IBD Patients

(HealthDay News) Heavy use of opiates among patients with inflammatory bowel diseases is tied to increased risk of premature all-cause death, according to research in Clinical Gastroenterology and Hepatology. Researchers examined opiate prescription and all-cause mortality trends among patients with Crohn’s disease or ulcerative colitis and found statistically significant increases in prescription and premature mortality rates from 1990 to 2013.

Thu, 19 Apr 2018 FAMILY PRACTICE
Marital Status Tied to Earlier Presentation of Melanoma

For patients with localized melanoma, marital status is associated with earlier T stage presentation, according to a study published in JAMA Dermatology. Researchers conducted a retrospective study using the Surveillance, Epidemiology, and End Results database of 18 population-based registered cancer institutes and found that 45.7% of married patients presented with T1a disease, compared with 43.0, 39.0, and 32.2% of never married, divorced, and widowed patients. Conversely, 9.4 and 3.3% of widowed and married patients, respectively, presented with T4b disease.

Thu, 19 Apr 2018 BREAKING NEWS