Longer Duration of Post-Op Opioid Use Associated with Misuse

Each refill and week of opioid prescription following surgery is associated with an increasing risk of opioid misuse among opioid naive patients, according to a study in The BMJ. Researchers found more than half of patients (56%) received postoperative opioids. A code for abuse was identified in less than 1% of patients (0.6%). The strongest predictor of misuse was total duration of opioid use, with each refill and additional week of opioid use associated with an adjusted increase in the rate of misuse.

Fri, 19 Jan 2018 BREAKING NEWS
Proinflammatory Diet Linked to Increased Colorectal Cancer Risk

(HealthDay News) Researchers examined correlations between an empirical dietary inflammatory pattern (EDIP) score and colorectal cancer risk in a cohort study of 46,804 men and 74,246 women followed for 26 years. Participants in the highest EDIP quartile had a colorectal cancer incidence rate of 151 and 92 per 100,000 person-years for men and women.

Onabotulinum Toxin-A Can Safely Improve Sleep Bruxism

(HealthDay News) Onabotulinum toxin-A (BoNT-A) injections can improve sleep bruxism, according to a study in Neurology. Researchers found that clinical global impression and visual analog scale of change in bruxism and in pain favored the BoNT-A group. “BoNT-A effectively and safely improved sleep bruxism in this placebo-controlled pilot trial,” the authors write.

Fri, 19 Jan 2018 FAMILY PRACTICE
Screening Mammography Up After Cost Sharing Eliminated

The elimination of cost sharing for screening mammography is associated with increased rates of use of the service, according to a study published in the New England Journal of Medicine. Researchers found that the adjusted rates of biennial screening mammography increased from 59.9 to 65.4% in the two-year periods before and after elimination of cost sharing. The rates of biennial mammography were 73.1 and 72.8% during the same periods in control plans, yielding a difference in differences of 5.7 percentage points.

Fri, 19 Jan 2018 BREAKING NEWS
Value of Doxylamine-Pyridoxine Questioned in Early Pregnancy

Doxylamine-pyridoxine may be beneficial for nausea and vomiting symptoms in early pregnancy, but the magnitude of the difference is very small and may indicate no clinically important benefit, according to a recent study. “There is a trend towards efficacy for nausea and vomiting symptoms with doxylamine-pyridoxine compared with placebo but the statistical significance of the difference depends on the method of handling missing data and the magnitude of the difference suggests that there is no clinically important benefit,” the authors write.

Fri, 19 Jan 2018 BREAKING NEWS
Alzheimer’s Disease Variants Linked to Brain Amyloidosis

Certain Alzheimer’s disease (AD) risk variants are associated with brain amyloidosis, according to research in JAMA Neurology. After apolipoprotein E ε4, the strongest correlation with amyloid deposition was seen for the adenosine triphosphate-binding cassette subfamily A member 7 (ABCA7) gene. There were significant correlations found between ABCA7 in the asymptomatic and early symptomatic disease stages. A stage-dependent association was seen for the fermitin family homolog 2 with brain amyloidosis, which was strongest in the mild cognitive impairment stage.

Thu, 18 Jan 2018 BREAKING NEWS