BREAKING NEWS
Longer Duration of Post-Op Opioid Use Associated with Misuse
 

Each refill and week of opioid prescription following surgery is associated with an increasing risk of opioid misuse among opioid naive patients, according to a study in The BMJ. Researchers found more than half of patients (56%) received postoperative opioids. A code for abuse was identified in less than 1% of patients (0.6%). The strongest predictor of misuse was total duration of opioid use, with each refill and additional week of opioid use associated with an adjusted increase in the rate of misuse.


Fri, 19 Jan 2018 BREAKING NEWS
Screening Mammography Up After Cost Sharing Eliminated
 

The elimination of cost sharing for screening mammography is associated with increased rates of use of the service, according to a study published in the New England Journal of Medicine. Researchers found that the adjusted rates of biennial screening mammography increased from 59.9 to 65.4% in the two-year periods before and after elimination of cost sharing. The rates of biennial mammography were 73.1 and 72.8% during the same periods in control plans, yielding a difference in differences of 5.7 percentage points.


Fri, 19 Jan 2018 BREAKING NEWS
Value of Doxylamine-Pyridoxine Questioned in Early Pregnancy
 

Doxylamine-pyridoxine may be beneficial for nausea and vomiting symptoms in early pregnancy, but the magnitude of the difference is very small and may indicate no clinically important benefit, according to a recent study. “There is a trend towards efficacy for nausea and vomiting symptoms with doxylamine-pyridoxine compared with placebo but the statistical significance of the difference depends on the method of handling missing data and the magnitude of the difference suggests that there is no clinically important benefit,” the authors write.


Fri, 19 Jan 2018 BREAKING NEWS
Alzheimer’s Disease Variants Linked to Brain Amyloidosis
 

Certain Alzheimer’s disease (AD) risk variants are associated with brain amyloidosis, according to research in JAMA Neurology. After apolipoprotein E ε4, the strongest correlation with amyloid deposition was seen for the adenosine triphosphate-binding cassette subfamily A member 7 (ABCA7) gene. There were significant correlations found between ABCA7 in the asymptomatic and early symptomatic disease stages. A stage-dependent association was seen for the fermitin family homolog 2 with brain amyloidosis, which was strongest in the mild cognitive impairment stage.


Thu, 18 Jan 2018 BREAKING NEWS
Adding HIPEC to Cytoreductive Surgery Beneficial in Ovarian CA
 

The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery is associated with improved outcomes in patients with stage III epithelial ovarian cancer, according to a study published in the New England Journal of Medicine. “Among patients with stage III epithelial ovarian cancer, the addition of HIPEC to interval cytoreductive surgery resulted in longer recurrence-free survival and overall survival than surgery alone and did not result in higher rates of side effects,” the authors write.


Thu, 18 Jan 2018 BREAKING NEWS
Brain Is Susceptible to Acute MI, Chronic Heart Failure
 

Acute myocardial infarction (MI) and chronic heart failure have effects on the brain, research in the Journal of the American College of Cardiology finds. Researchers examined the influence of MI on cardiac and brain inflammation using noninvasive positron emission tomography (PET) of the heart-brain axis. They found that brain mitochondrial translocator protein (TSPO) was elevated in parallel at one week post infarct, and progressive heart failure precipitated a second wave of neuroinflammation after interval decline at four weeks.


Thu, 18 Jan 2018 BREAKING NEWS